Tegafur-induced acral hyperpigmentation
نویسندگان
چکیده
Tegafur is a prodrug of 5-fluorouracil (5-FU) with a similar spectrum of antitumor activity. It is used in the treatment of advanced gastrointestinal neoplasms. Over 5-FU, tegafur has the advantage of oral administration and less hematologic toxicity. Gastrointestinal toxicity is its main dose-limiting factor. The cutaneous adverse effects of tegafur include mucositis, photosensitivity, diffuse or nail-restricted hyperpigmentation, palmoplantar erythrodysesthesia syndrome, palmoplantar keratoderma, sclerodactyly and Raynaud phenomenon. We report here the case of a patient who developed acral hyperpigmentation during treatment with tegafur.
منابع مشابه
Black lunula caused by Tegafur.
Sir, Tegafur, a fluorinated pyrimidine analogue of 5Fluorouracil (5-FU), is metabolized in vivo with biotransformation to 5-FU (1). It is effective in the treatment of gastrointestinal carcinoma, with the advantages of low myelosuppression and lack of immunosuppression. The cutaneous adverse effects of Tegafur include stomatitis, dry skin, disseminated rash, alopecia, photosensitivity, palmopla...
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